Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective.

doi:10.1093/neuonc/not043

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Article

Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective.

Neuro-oncology - 1 Aug 2013

Wiestler Benedikt, Claus Rainer, Hartlieb Sabine A, Schliesser Maximilian G, Weiss Elisa K, Hielscher Thomas, Platten Michael, Dittmann Laura M, Meisner Christoph, Felsberg Jörg, Happold Caroline, Simon Matthias, Nikkhah Guido, Papsdorf Kirsten, Steinbach Joachim P, Sabel Michael, Grimm Christiane, Weichenhan Dieter, Tews Björn, Reifenberger Guido, Capper David, Müller Wolf, Plass Christoph, Weller Michael, Wick Wolfgang

Abstract excerpt

BACKGROUND: The number of patients age >65 years with malignant gliomas is increasing. Prognosis of these patients is worse compared with younger patients. To determine biological differences among malignant gliomas of different age groups and help to explain the survival heterogeneity seen in the NOA-08 trial, the prevalence and impact of recently established biomarkers for outcome in younger patients were...

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PMID: 23595628
DOI: 10.1093/neuonc/not043
PMCID: PMC3714152

Genes

IDH1
PRDX1
MGMT

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