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Article

Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.

Journal of neuro-oncology - 1 May 2015

Mur Pilar, Rodríguez de Lope Ángel, Díaz-Crespo Francisco Javier, Hernández-Iglesias Teresa, Ribalta Teresa, Fiaño Concepción, García Juan Fernando, Rey Juan Antonio, Mollejo Manuela, Meléndez Bárbara

Abstract excerpt

Clinical and molecular prognostic factors in gliomas include age, IDH mutation, the glioma CpG island methylator phenotype (G-CIMP+) and promoter methylation of the O(6)-methylguanine DNA-methyltransferase (MGMT) gene. Among these markers, a predictive value was reported in glioblastomas (GBM) for MGMT promoter methylation, in particular in elderly GBM patients. In this study, methylation data from 46 glioma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25682093
DOI: 10.1007/s11060-015-1738-9

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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