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Article

Next-generation sequencing (NGS) analysis and age-based survival comparison among glioblastoma (GBM) patients: a two-center cohort study.

Acta neurochirurgica - 23 Jun 2026

Lee Chul Ou, Park Sun Yong, Yun Yejin, Choi Ju Young, Park Jae-Sung, Jeun Sin-Soo, Kim Yeo Song

Abstract excerpt

OBJECTIVE: Glioblastoma (GBM) incidence increases with age, and its etiologies may differ between young and elderly patients. This study aimed to investigate genetic differences between young and elderly GBM patients using next-generation sequencing (NGS) data. METHODS: We retrospectively analyzed 124 GBM patients (< 65 years, n = 60; ≥ 65 years, n = 64) who underwent surgery at two institutions between 2017 and...

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Identifiers

PMID: 42334679
DOI: 10.1007/s00701-026-06924-1
PMCID: PMC13415257

Genes

MGMT
ATRX
CDK6
MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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