Article
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
International journal of cancer - 15 Nov 2018
Ostrom Quinn T, Kinnersley Ben, Armstrong Georgina, Rice Terri, Chen Yanwen, Wiencke John K, McCoy Lucie S, Hansen Helen M, Amos Christopher I, Bernstein Jonine L, Claus Elizabeth B, Eckel-Passow Jeanette E, Il'yasova Dora, Johansen Christoffer, Lachance Daniel H, Lai Rose K, Merrell Ryan T, Olson Sara H, Sadetzki Siegal, Schildkraut Joellen M, Shete Sanjay, Rubin Joshua B, Andersson Ulrika, Rajaraman Preetha, Chanock Stephen J, Linet Martha S, Wang Zhaoming, Yeager Meredith, Houlston Richard S, Jenkins Robert B, Wrensch Margaret R, Melin Beatrice, Bondy Melissa L, Barnholtz-Sloan Jill S
Abstract excerpt
Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs and age-at-diagnosis has been explored, genome-wide association studies (GWAS) have not previously been stratified by age. Potential age-specific genetic...
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