Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma.

doi:10.1093/neuonc/noaf287

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma.

Neuro-oncology - 1 Mar 2026

Youssef Gilbert, Aquilanti Elisa, Miller Julie J, Lan Zhou, Lasica Aleksandra B, Arrillaga-Romany Isabel, Batchelor Tracy T, Berger Tamar R, Beroukhim Rameen, Chukwueke Ugonma, Dietrich Jorg, Forst Deborah A, Gerstner Elizabeth R, Castro L Nicolas Gonzalez, Jordan Justin T, Mcfaline-Figueroa J Ricardo, Lee Eudocia Quant, Nayak Lakshmi, Nakhate Vihang, Ospina Juan Pablo, Plotkin Scott R, Wang Nancy, Rhee John Y, Reardon David A, Wen Patrick Y

Abstract excerpt

BACKGROUND: The prognostic and predictive value of O6-methylguanine-DNA methyltransferase promoter (MGMTp) methylation is not well established in isocitrate dehydrogenase (IDH)-mutant gliomas. This study evaluates the survival impact of MGMTp and other clinical, molecular, and radiologic variables in low-grade and high-grade IDH-mutant gliomas. METHODS: We retrospectively evaluated 520 consecutive adult patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Survival Rate

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41397912
DOI: 10.1093/neuonc/noaf287
PMCID: PMC13070496

Genes

CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic significance of O6-methylguanine-DNA methyltransferase promoter methylation status in isocitrate dehydrogenase-mutant glioma.PMID 41397912Read ↗

Prognostic value of O6-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomasSemantic proximity Read ↗

Clinical value of the MGMT promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatmentSemantic proximity Read ↗

Impact of IDH mutation and MGMT methylation as Independent prognostic markers in uniformly treated high grade glioma Patients: A Real-World evidence in the Indian Population.Semantic proximity Read ↗

The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: How should they inform treatment decisions in the era of IDH inhibitors?Semantic proximity Read ↗

Association of MGMT Promoter Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating ChemotherapySemantic proximity Read ↗

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.Semantic proximity Read ↗

Prognostic value of MGMT promoter methylation and TP53 mutation in glioblastomas depends on IDH1 mutation.Semantic proximity Read ↗

Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications.Semantic proximity Read ↗

Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.Semantic proximity Read ↗

Multidisciplinary Management of Isocitrate Dehydrogenase-Mutated Gliomas in a Contemporary Molecularly Defined Era.Semantic proximity Read ↗

IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry.Semantic proximity Read ↗

Surgery for Glioblastoma in Light of Molecular Markers: Impact of Resection and MGMT Promoter Methylation in Newly Diagnosed IDH-1 Wild-Type GlioblastomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.