Article
Genetics of toll like receptor 9 in ANCA associated vasculitides.
Annals of the rheumatic diseases - 1 May 2014
Husmann C A, Holle J U, Moosig F, Mueller S, Wilde B, Cohen Tervaert J W, Harper L, Assmann G, Gross W L, Epplen J T, Wieczorek S
Abstract excerpt
OBJECTIVES: To investigate the contribution of genetic polymorphisms of toll like receptor (TLR) 9 and related genes on the susceptibility and clinical manifestation of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV). METHODS: Four single nucleotide polymorphisms (SNPs) in TLR9 were genotyped in 863 German AAV cases and 1344 healthy controls. Significant results were replicated in a...
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