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Article

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis.

Frontiers in immunology - 1 Jan 2021

Li Weiran, Huang He, Cai Minglong, Yuan Tao, Sheng Yujun

Abstract excerpt

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the inflammation of small and medium vessels and presence of proteinase 3-ANCA or myeloperoxidase-ANCA in the circulation. AAV comprises three clinical subtypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (EGPA). Although the pathogenesis of AAV is still unclear, genetic and...

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Identifiers

PMID: 33841406
DOI: 10.3389/fimmu.2021.624848
PMCID: PMC8032971

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