Article
Single nucleotide polymorphisms in the toll-like receptor 2 (TLR2) gene are associated with microscopic polyangiitis in the northern Han Chinese population.
Modern rheumatology - 1 Mar 2015
Wu Ziyan, Xu Juanjuan, Sun Fei, Chen Hua, Wu Qingjun, Zheng Wenjie, Li Ping, Bai Yina, Zhang Fengchun, Li Yongzhe
Abstract excerpt
OBJECTIVES: Our study was designed to evaluate the association of single nucleotide polymorphisms (SNPs) of the TLR2 gene with antineutrophil cytoplasmic autoantibodies (ANCAs)-associated vasculitides (AAV) in the northern Han Chinese population. METHODS: The TLR2 SNPs rs1898830, rs11938228, rs3804099, rs3804100, and rs7656411 were analyzed in 195 AAV patients [granulomatosis with polyangiitis (GPA), n = 100;...