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Article

Meta-analysis revealed HLA susceptibility markers in ANCA-associated vasculitis and its clinical subtypes.

Rheumatology (Oxford, England) - 1 Oct 2025

Singh Harinder, Maiti Koustav, Saha Sohini, Senapati Sabyasachi

Abstract excerpt

OBJECTIVES: ANCA-associated vasculitis (AAV) is a group of systemic autoimmune diseases affecting small blood-vessels. Class-II human leukocyte antigen (HLA) genes are often reported as major genetic determinants. We conducted a systematic review and meta-analysis to evaluate the susceptibility conferred by HLA genes to AAV and five of its clinical subtypes [PR3+AAV, MPO+AAV, granulomatosis with polyangiitis...

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Alleles
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MPO gene
Genetic Predisposition to Disease
Granulomatosis with Polyangiitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Otitis Media and Relapsing Polychondritis

Vasculitis and related conditions

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Identifiers

PMID: 40397991
DOI: 10.1093/rheumatology/keaf265

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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