Article

The genetics of anti-neutrophil cytoplasmic antibody associated vasculitis (AAV)

2020-01-01

Abstract excerpt

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a multi-systemic autoimmune disorder with evidence of circulating pathogenic ANCA. There are two main antigenic targets: proteinase 3 (PR3) and myeloperoxidase (MPO). Previous genome-wide association studies (GWAS) have provided evidence that PR3-AAV and MPO-AAV are genetically distinct autoimmune syndromes, though only three loci specific...

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Literature Corpus work: 2b7f9b93-5bfc-54b2-a96f-3729c0b916cc
DOI: 10.17863/cam.51022

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