Article
Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2017
Merkel Peter A, Xie Gang, Monach Paul A, Ji Xuemei, Ciavatta Dominic J, Byun Jinyoung, Pinder Benjamin D, Zhao Ai, Zhang Jinyi, Tadesse Yohannes, Qian David, Weirauch Matthew, Nair Rajan, Tsoi Alex, Pagnoux Christian, Carette Simon, Chung Sharon, Cuthbertson David, Davis John C, Dellaripa Paul F, Forbess Lindsy, Gewurz-Singer Ora, Hoffman Gary S, Khalidi Nader, Koening Curry, Langford Carol A, Mahr Alfred D, McAlear Carol, Moreland Larry, Seo E Philip, Specks Ulrich, Spiera Robert F, Sreih Antoine, St Clair E William, Stone John H, Ytterberg Steven R, Elder James T, Qu Jia, Ochi Toshiki, Hirano Naoto, Edberg Jeffrey C, Falk Ronald J, Amos Christopher I, Siminovitch Katherine A
Abstract excerpt
OBJECTIVE: To identify risk alleles relevant to the causal and biologic mechanisms of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: A genome-wide association study and subsequent replication study were conducted in a total cohort of 1,986 cases of AAV (patients with granulomatosis with polyangiitis [Wegener's] [GPA] or microscopic polyangiitis [MPA]) and 4,723 healthy controls....
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