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Article

Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.

Genetics - 1 Dec 2014

Tien Jerry F, Umbreit Neil T, Zelter Alex, Riffle Michael, Hoopmann Michael R, Johnson Richard S, Fonslow Bryan R, Yates John R, MacCoss Michael J, Moritz Robert L, Asbury Charles L, Davis Trisha N

Abstract excerpt

Accurate transmission of genetic material relies on the coupling of chromosomes to spindle microtubules by kinetochores. These linkages are regulated by the conserved Aurora B/Ipl1 kinase to ensure that sister chromatids are properly attached to spindle microtubules. Kinetochore-microtubule attachments require the essential Ndc80 complex, which contains two globular ends linked by large coiled-coil domains. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25230952
DOI: 10.1534/genetics.114.167775
PMCID: PMC4256767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.PMID 25230952Read ↗

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