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Article

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.

Nature cell biology - 1 Apr 2015

Kalantzaki Maria, Kitamura Etsushi, Zhang Tongli, Mino Akihisa, Novák Béla, Tanaka Tomoyuki U

Abstract excerpt

For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B kinase (Ipl1 in budding yeast). Paradoxically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25751138
DOI: 10.1038/ncb3128
PMCID: PMC4380510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25751138-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.PMID 25751138Read ↗

Aurora B switches relative strength of kinetochore-microtubule attachment modes for error correction.Semantic proximity Read ↗

Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.Semantic proximity Read ↗

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

Captivating capture: how microtubules attach to kinetochores.Semantic proximity Read ↗

Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.Semantic proximity Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.Semantic proximity Read ↗

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Semantic proximity Read ↗

Measuring and modeling the dynamics of mitotic error correctionSemantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

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