Article
The Ndc80 kinetochore complex directly modulates microtubule dynamics.
Proceedings of the National Academy of Sciences of the United States of America - 2 Oct 2012
Umbreit Neil T, Gestaut Daniel R, Tien Jerry F, Vollmar Breanna S, Gonen Tamir, Asbury Charles L, Davis Trisha N
Abstract excerpt
The conserved Ndc80 complex is an essential microtubule-binding component of the kinetochore. Recent findings suggest that the Ndc80 complex influences microtubule dynamics at kinetochores in vivo. However, it was unclear if the Ndc80 complex mediates these effects directly, or by affecting other factors localized at the kinetochore. Using a reconstituted system in vitro, we show that the human Ndc80 complex...
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