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Article

Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments.

Current biology : CB - 16 Nov 2020

Gutierrez Abraham, Kim Jae Ook, Umbreit Neil T, Asbury Charles L, Davis Trisha N, Miller Matthew P, Biggins Sue

Abstract excerpt

To ensure the faithful inheritance of DNA, a macromolecular protein complex called the kinetochore sustains the connection between chromosomes and force-generating dynamic microtubules during cell division. Defects in this process lead to aneuploidy, a common feature of cancer cells and the cause of many developmental diseases [1-4]. One of the major microtubule-binding activities in the kinetochore is mediated...

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Share to CDC28 Protein Kinase, S cerevisiae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32946748
DOI: 10.1016/j.cub.2020.08.054
PMCID: PMC7497780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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