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Article

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.

Scientific reports - 19 Sept 2017

Jin Fengzhi, Bokros Michael, Wang Yanchang

Abstract excerpt

The interaction between chromosomes and spindle microtubules is essential for chromosome segregation. The kinetochore complex mediates this interaction. Previous studies indicate that the stability of kinetochore attachment is regulated by Aurora B/Ipl1 kinase and this regulation is conserved from yeast to mammalian cells. In budding yeast Saccharomyces cerevisiae, the ten-subunit Dam1/DASH complex bridges the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28928489
DOI: 10.1038/s41598-017-12329-z
PMCID: PMC5605499

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The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.PMID 28928489Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.Semantic proximity Read ↗

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.Semantic proximity Read ↗

Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Semantic proximity Read ↗

CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.Semantic proximity Read ↗

Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.Semantic proximity Read ↗

Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase.Semantic proximity Read ↗

A pathway containing the Ipl1/aurora protein kinase and the spindle midzone protein Ase1 regulates yeast spindle assembly.Semantic proximity Read ↗

Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.Semantic proximity Read ↗

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