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Article

Domain III S4 in closed-state fast inactivation: insights from a periodic paralysis mutation.

Channels (Austin, Tex.) - 1 Jan 2014

Groome James R, Jurkat-Rott Karin, Lehmann-Horn Frank

Abstract excerpt

Heterologous expression of sodium channel mutations in hypokalemic periodic paralysis reveals 2 variants on channel dysfunction. Charge-reducing mutations of voltage sensing S4 arginine residues alter channel gating as typically studied with expression in mammalian cells. These mutations also produce leak currents through the voltage sensor module, as typically studied with expression in Xenopus oocytes. DIIIS4...

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Identifiers

PMID: 25483590
DOI: 10.4161/19336950.2014.958924
PMCID: PMC4594372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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