Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

doi:10.1371/journal.pone.0028931

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Article

Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

PloS one - 1 Jan 2012

Hernesniemi Jussi A, Seppälä Ilkka, Lyytikäinen Leo-Pekka, Mononen Nina, Oksala Niku, Hutri-Kähönen Nina, Juonala Markus, Taittonen Leena, Smith Erin N, Schork Nicholas J, Chen Wei, Srinivasan Sathanur R, Berenson Gerald S, Murray Sarah S, Laitinen Tomi, Jula Antti, Kettunen Johannes, Ripatti Samuli, Laaksonen Reijo, Viikari Jorma, Kähönen Mika, Raitakari Olli T, Lehtimäki Terho

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve already known associations and discovered thirteen new SNPs associating with CAD. We examined whether the...

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PMID: 22295058
DOI: 10.1371/journal.pone.0028931
PMCID: PMC3266236

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