Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling.

doi:10.1016/j.atherosclerosis.2011.08.031

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Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling.

Atherosclerosis - 1 Dec 2011

Conde Lucia, Bevan Steve, Sitzer Matthias, Klopp Norman, Illig Thomas, Thiery Joachim, Seissler Joachim, Baumert Jens, Raitakari Olli, Kähönen Mika, Lyytikäinen Leo-Pekka, Laaksonen Reijo, Viikari Jorma, Lehtimäki Terho, Koernig Wolfgang, Halperin Eran, Markus Hugh S

Abstract excerpt

BACKGROUND: Recent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT) is a measure of early arterial remodeling and arteriosclerosis. Therefore, if CAD associated SNPs are also associated with carotid IMT; it suggests that they...

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PMID: 21924425
DOI: 10.1016/j.atherosclerosis.2011.08.031

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