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Article

HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression.

Molecular cancer research : MCR - 4 May 2022

Di Segni Micol, Virdia Ilaria, Verdina Alessandra, Amoreo Carla Azzurra, Baldari Silvia, Toietta Gabriele, Diodoro Maria Grazia, Mottolese Marcella, Sperduti Isabella, Moretti Fabiola, Buglioni Simonetta, Soddu Silvia, Di Rocco Giuliana

Abstract excerpt

Homeodomain-interacting protein kinase 2 (HIPK2) is an evolutionary conserved kinase that has gained attention as a fine tuner of multiple signaling pathways, among which those commonly altered in colorectal cancer. The aim of this study was to evaluate the relationship of HIPK2 expression with progression markers and mutational pattern and gain insights into the contribution of HIPK2 activity in colorectal...

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Identifiers

PMID: 35082165
DOI: 10.1158/1541-7786.MCR-21-0628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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