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Article

Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice.

PloS one - 28 Apr 2010

Labalette Charlotte, Nouët Yann, Levillayer Florence, Colnot Sabine, Chen Ju, Claude Valere, Huerre Michel, Perret Christine, Buendia Marie-Annick, Wei Yu

Abstract excerpt

BACKGROUND: The four and a half LIM-only protein 2 (FHL2) is capable of shuttling between focal adhesion and nucleus where it signals through direct interaction with a number of proteins including beta-catenin. Although FHL2 activation has been found in various human cancers, evidence of its functional contribution to carcinogenesis has been lacking. METHODOLOGY/PRINCIPAL FINDINGS: Here we have investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20442768
DOI: 10.1371/journal.pone.0010371
PMCID: PMC2860980

Genes

FHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice.PMID 20442768Read ↗

Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1.Semantic proximity Read ↗

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2.Semantic proximity Read ↗

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferationSemantic proximity Read ↗

Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.Semantic proximity Read ↗

Entopic overexpression of Ascl2 does not accelerate tumourigenesis in Apc Min miceSemantic proximity Read ↗

The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.Semantic proximity Read ↗

The armadillo repeat domain of Apc suppresses intestinal tumorigenesis.Semantic proximity Read ↗

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.Semantic proximity Read ↗

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.Semantic proximity Read ↗

Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis.Semantic proximity Read ↗

FHL2 Silencing Reduces Wnt Signaling and Osteosarcoma Tumorigenesis In Vitro and In VivoSemantic proximity Read ↗

Deficiency of FHL2 attenuates airway inflammation in mice and genetic variation associates with human bronchial hyper-responsiveness.Semantic proximity Read ↗

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