Article
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
Nature genetics - 1 Jun 2013
Zhang Jinghui, Wu Gang, Miller Claudia P, Tatevossian Ruth G, Dalton James D, Tang Bo, Orisme Wilda, Punchihewa Chandanamali, Parker Matthew, Qaddoumi Ibrahim, Boop Fredrick A, Lu Charles, Kandoth Cyriac, Ding Li, Lee Ryan, Huether Robert, Chen Xiang, Hedlund Erin, Nagahawatte Panduka, Rusch Michael, Boggs Kristy, Cheng Jinjun, Becksfort Jared, Ma Jing, Song Guangchun, Li Yongjin, Wei Lei, Wang Jianmin, Shurtleff Sheila, Easton John, Zhao David, Fulton Robert S, Fulton Lucinda L, Dooling David J, Vadodaria Bhavin, Mulder Heather L, Tang Chunlao, Ochoa Kerri, Mullighan Charles G, Gajjar Amar, Kriwacki Richard, Sheer Denise, Gilbertson Richard J, Mardis Elaine R, Wilson Richard K, Downing James R, Baker Suzanne J, Ellison David W
Abstract excerpt
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX, in 39 LGGs and low-grade glioneuronal tumors (LGGNTs). Only a single non-silent somatic alteration was detected in 24 of 39 (62%) tumors. Intragenic duplications...
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