Article
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 2013
Ramkissoon Lori A, Horowitz Peleg M, Craig Justin M, Ramkissoon Shakti H, Rich Benjamin E, Schumacher Steven E, McKenna Aaron, Lawrence Michael S, Bergthold Guillaume, Brastianos Priscilla K, Tabak Barbara, Ducar Matthew D, Van Hummelen Paul, MacConaill Laura E, Pouissant-Young Tina, Cho Yoon-Jae, Taha Hala, Mahmoud Madeha, Bowers Daniel C, Margraf Linda, Tabori Uri, Hawkins Cynthia, Packer Roger J, Hill D Ashley, Pomeroy Scott L, Eberhart Charles G, Dunn Ian F, Goumnerova Liliana, Getz Gad, Chan Jennifer A, Santagata Sandro, Hahn William C, Stiles Charles D, Ligon Azra H, Kieran Mark W, Beroukhim Rameen, Ligon Keith L
Abstract excerpt
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especially challenging clinically. We performed high-resolution copy-number analysis on 44 formalin-fixed,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.