Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.

doi:10.1016/j.ccell.2020.03.011

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Article

Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.

Cancer cell - 13 Apr 2020

Ryall Scott, Zapotocky Michal, Fukuoka Kohei, Nobre Liana, Guerreiro Stucklin Ana, Bennett Julie, Siddaway Robert, Li Christopher, Pajovic Sanja, Arnoldo Anthony, Kowalski Paul E, Johnson Monique, Sheth Javal, Lassaletta Alvaro, Tatevossian Ruth G, Orisme Wilda, Qaddoumi Ibrahim, Surrey Lea F, Li Marilyn M, Waanders Angela J, Gilheeney Stephen, Rosenblum Marc, Bale Tejus, Tsang Derek S, Laperriere Normand, Kulkarni Abhaya, Ibrahim George M, Drake James, Dirks Peter, Taylor Michael D, Rutka James T, Laughlin Suzanne, Shroff Manohar, Shago Mary, Hazrati Lili-Naz, D'Arcy Colleen, Ramaswamy Vijay, Bartels Ute, Huang Annie, Bouffet Eric, Karajannis Matthias A, Santi Mariarita, Ellison David W, Tabori Uri, Hawkins Cynthia

Abstract excerpt

Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in their clinical outcome. To address this, we characterized a cohort of >1,000 clinically annotated pLGG. Eighty-four percent of cases harbored a driver alteration, while those without an identified alteration also often exhibited...

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Identifiers

PMID: 32289278
DOI: 10.1016/j.ccell.2020.03.011
PMCID: PMC7169997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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