Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.

doi:10.1007/s00401-016-1539-z

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Article

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.

Acta neuropathologica - 1 Jun 2016

Qaddoumi Ibrahim, Orisme Wilda, Wen Ji, Santiago Teresa, Gupta Kirti, Dalton James D, Tang Bo, Haupfear Kelly, Punchihewa Chandanamali, Easton John, Mulder Heather, Boggs Kristy, Shao Ying, Rusch Michael, Becksfort Jared, Gupta Pankaj, Wang Shuoguo, Lee Ryan P, Brat Daniel, Peter Collins V, Dahiya Sonika, George David, Konomos William, Kurian Kathreena M, McFadden Kathryn, Serafini Luciano Neder, Nickols Hilary, Perry Arie, Shurtleff Sheila, Gajjar Amar, Boop Fredrick A, Klimo Paul D, Mardis Elaine R, Wilson Richard K, Baker Suzanne J, Zhang Jinghui, Wu Gang, Downing James R, Tatevossian Ruth G, Ellison David W

Abstract excerpt

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children and young adults, often with a history of epilepsy. While the genetic profiles of common LGNTs, such as the pilocytic astrocytoma and 'adult-type' diffuse gliomas, are largely established, those of uncommon LGNTs remain to be defined. In this study, we have used massively parallel sequencing and various targeted molecular...

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Identifiers

PMID: 26810070
DOI: 10.1007/s00401-016-1539-z
PMCID: PMC4866893

Genes

MYB
BRAF
FGFR1
EWSR1
IDH1
MYBL1
NTRK2
PATZ1
QKI
SLMAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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