Article
Antithrombin is protective against myocardial ischemia and reperfusion injury.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2013
Wang J, Wang Y, Wang J, Gao J, Tong C, Manithody C, Li J, Rezaie A R
Abstract excerpt
BACKGROUND: Antithrombin (AT) is a plasma serpin inhibitor that regulates the proteolytic activity of procoagulant proteases of the clotting cascade. In addition to its anticoagulant activity, AT also possesses potent anti-inflammatory properties. OBJECTIVES: The objective of this study was to investigate the anti-inflammatory activity of wild-type AT (AT-WT) and a reactive centre loop mutant of AT (AT-RCL) which...
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