Article
Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction.
Circulation - 26 Feb 2008
Salio Monica, Chimenti Stefano, De Angelis Noeleen, Molla Fabiola, Maina Virginia, Nebuloni Manuela, Pasqualini Fabio, Latini Roberto, Garlanda Cecilia, Mantovani Alberto
Abstract excerpt
BACKGROUND: Despite widespread clinical use as a prognostic marker in ischemic heart disorders, the actual pathogenetic role of the short pentraxin, C-reactive protein, has not undergone stringent genetic testing because of evolutionary divergence between mouse and humans. The long pentraxin PTX3 is conserved in evolution, is expressed in the heart under inflammatory conditions, and is a candidate prognostic...
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