Article
Thiopurine S-Methyltransferase gene polymorphisms in a healthy Slovak population and pediatric patients with inflammatory bowel disease.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2013
Chocholova Alica, Soltysova Andrea, Minarik Gabriel, Cierna Iveta, Sufliarska Sabina, Mladosievicova Beata
Abstract excerpt
Thiopurine methyltransferase (TPMT) is a key component in thiopurine metabolism. There is an insufficient evidence about the distribution of the genotype frequencies of TPMT variants and frequencies of TPMT alleles associated with intermediate and deficient activity in a healthy Slovak population and pediatric patients with inflammatory bowel disease (IBD). TPMT variant alleles (*1,*2, *3A, *3B, and *3C) were...
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