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Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

15 May 2011

Abstract excerpt

Azathioprine (AZA), 6-mercaptopurine (6-MP), and thioguanine (TG) are thiopurine drugs. These agents are indicated for the treatment of various diseases including hematologic malignancies, inflammatory bowel disease (IBD), rheumatoid arthritis, and as immunosuppressants in solid organ transplants. Thiopurine drugs are metabolized, in part, by thiopurine methyltransferase (TPMT). TPMT displays genetic polymorphism...

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PMID: 21593964
DOI: 10.1371/currents.rrn1236

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