Article
TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Dec 2005
Stocco G, Martelossi S, Barabino A, Fontana M, Lionetti P, Decorti G, Malusà N, Bartoli F, Fezzi M, Giraldi T, Ventura A
Abstract excerpt
BACKGROUND: Thiopurines are used in the treatment of inflammatory bowel disease. They are metabolised via methylation by thiopurine-S-methyltransferase (TPMT), which displays a genetically determined polymorphic activity. Subjects with reduced TPMT activity have a higher concentration of active thiopurine metabolites and may be at increased risk of bone-marrow suppression. AIMS: To evaluate the relevance of TPMT...
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