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Article

Thiopurine S-methyltransferase genotype and the use of thiopurines in paediatric inflammatory bowel disease Greek patients.

Journal of clinical pharmacy and therapeutics - 1 Feb 2010

Gazouli M, Pachoula I, Panayotou I, Mantzaris G, Syriopoulou V P, Goutas N, Vlachodimitropoulos D, Anagnou N P, Roma-Giannikou E

Abstract excerpt

BACKGROUND AND OBJECTIVE: Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of paediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP. The aim of the present study was to investigate the frequency of the functional TPMT polymorphisms and...

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Identifiers

PMID: 20175817
DOI: 10.1111/j.1365-2710.2009.01041.x

Genes

TPMT

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