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Article

Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease.

European journal of drug metabolism and pharmacokinetics - 1 Dec 2013

Ben Salah Lynda, Belkhiria el Haj Amor Mouna, Chbili Chahra, Khlifi Saida, Fathallah Neila, Bougmiza Iheb, Ben Jazia Elhem, Houdret Nicole, Ben Salem Chaker, Saguem Saad

Abstract excerpt

This study was conducted to investigate the thiopurine S-methyltransferase TPMT activity distribution and gene mutations in Tunisian population with positive diagnostic for Crohn's disease. TPMT activity was measured in Tunisian population (n = 88) by a high performance liquid chromatography assay. Polymerase chain reaction-based methods were used to determine the frequency of TPMT mutant alleles TPMT*2, TPMT*3A,...

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Source

Identifiers

PMID: 23553048
DOI: 10.1007/s13318-013-0127-z

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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