Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.

Acta clinica Croatica - 1 Mar 2016

Ladić Agata, Božina Nada, Borzan Vladimir, Brinar Marko, Vucelić Boris, Cuković-Cavka Silvija

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is an enzyme that converts thiopurine drugs into inactive metabolites. Over 20 variant TPMT-encoding alleles, which cause reduced enzymatic activity, have been discovered so far. Our aim was to investigate the frequencies of variant alleles, i.e. genotypes in inflammatory bowel disease (IBD) patients and healthy individuals and to compare these frequencies with selected world...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Croatia

Share to Crohn Disease

Share to Epidemiologic Studies

Share to Homozygote

Share to Inflammatory Bowel Diseases

Share to Methyltransferases

Source

Identifiers

PMID: 27333713

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.PMID 27333713Read ↗

Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.Semantic proximity Read ↗

Thiopurine S-Methyltransferase gene polymorphisms in a healthy Slovak population and pediatric patients with inflammatory bowel disease.Semantic proximity Read ↗

Thiopurine-methyltransferase variants in inflammatory bowel disease: prevalence and toxicity in Brazilian patients.Semantic proximity Read ↗

Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease.Semantic proximity Read ↗

Prevalence of mutations in thiopurine S-methyltransferase gene among Slovak IBD patients.Semantic proximity Read ↗

Prevalence of mutations in thiopurine S-methyltransferase gene among Slovak IBD patients.Semantic proximity Read ↗

High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease.Semantic proximity Read ↗

Frequency of thiopurine methyltransferase mutation in patients of Mediterranean area with inflammatory bowel disease and autoimmune disorders.Semantic proximity Read ↗

Analysis of thiopurine S-methyltransferase phenotype-genotype in a Tunisian population with Crohn's disease.Semantic proximity Read ↗

Thiopurine methyltransferase gene polymorphisms in Chinese patients with inflammatory bowel disease.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.