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Article

Whole-Blood Thiopurine S-Methyltransferase Genotype and Phenotype Concordance in Iranian Kurdish Ulcerative Colitis (UC) Patients.

Clinical laboratory - 1 May 2017

Bahrehmand Fariborz, Vaisi-Raygani Asad, Kiani Amir, Bashiri Homayoun, Zobeiri Mahdi, Tanhapour Maryam, Pourmotabbed Tayebeh

Abstract excerpt

BACKGROUND: Thiopurine methyl transferase (TPMT), a drug-metabolizing enzyme, catalyzes methylation and consequently, the metabolism of thiopurine compounds used for treatment of inflammatory bowel disease (IBD). Individuals who are homozygous recessive or have extremely low TPMT activity need to avoid thiopurines because of concern for significant leukopenia. The aim of this research was to determine TPMT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28627831
DOI: 10.7754/Clin.Lab.2017.161201

Genes

TPMT

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