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Article

Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans.

The Journal of clinical investigation - 1 Mar 2005

Azizi Michel, Boutouyrie Pierre, Bissery Alvine, Agharazii Mohsen, Verbeke Francis, Stern Nora, Bura-Rivière Alessandra, Laurent Stéphane, Alhenc-Gelas François, Jeunemaitre Xavier

Abstract excerpt

Tissue kallikrein (TK), the major kinin-forming enzyme, is synthesized in several organs, including the kidney and arteries. A loss-of-function polymorphism of the human TK gene (R53H) induces a substantial decrease in enzyme activity. As inactivation of the TK gene in the mouse induces endothelial dysfunction, we investigated the vascular, hormonal, and renal phenotypes of carriers of the 53H allele. In a...

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Identifiers

PMID: 15765151
DOI: 10.1172/JCI23669
PMCID: PMC1052005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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