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Article

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait.

Thrombosis and haemostasis - 1 Jun 2012

Bird J Eileen, Smith Patricia L, Wang Xinkang, Schumacher William A, Barbera Frank, Revelli Jean-Pierre, Seiffert Dietmar

Abstract excerpt

Plasma kallikrein is a multifunctional serine protease involved in contact activation of coagulation. Deficiency in humans is characterised by prolonged activated partial thromboplastin time (aPTT); however, the balance between thrombosis and haemostasis is not fully understood. A study of plasma kallikrein-deficient mice revealed increased aPTT, without prolonged bleeding time. Prekallikrein antisense...

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PMID: 22398951
DOI: 10.1160/th-11-10-0682

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