Article
Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects.
Journal of hypertension - 1 Oct 2006
Rossi Gian Paolo, Taddei Stefano, Ghiadoni Lorenzo, Virdis Agostino, Zavattiero Silvia, Favilla Stefania, Versari Daniele, Sudano Isabella, Azizi Michel, Vedie Benoit, Pessina Achille C, Salvetti Antonio, Jeunemaitre Xavier
Abstract excerpt
BACKGROUND: Tissue kallikrein (TK) generates Lys-bradykinin, which is then converted to bradykinin and releases nitric oxide (NO) from endothelial cells via B2 receptors. TK gene inactivation in mice causes severe endothelial dysfunction, which is also a hallmark of human primary hypertension (PH). Healthy carriers of a loss-of-function Arg to His substitution at position 53 (R53H) of the TK gene exhibit...
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