Article
Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001
Meneton P, Bloch-Faure M, Hagege A A, Ruetten H, Huang W, Bergaya S, Ceiler D, Gehring D, Martins I, Salmon G, Boulanger C M, Nussberger J, Crozatier B, Gasc J M, Heudes D, Bruneval P, Doetschman T, Ménard J, Alhenc-Gelas F
Abstract excerpt
Tissue kallikrein is a serine protease thought to be involved in the generation of bioactive peptide kinins in many organs like the kidneys, colon, salivary glands, pancreas, and blood vessels. Low renal synthesis and urinary excretion of tissue kallikrein have been repeatedly linked to hypertension in animals and humans, but the exact role of the protease in cardiovascular function has not been established...
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