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Article

A rapid association test procedure robust under different genetic models accounting for population stratification.

Human heredity - 1 Jan 2013

Chen Wenan, Chen Xiangning, Archer Kellie J, Liu Nianjun, Li Qizhai, Zhao Zhongming, Sun Shumei, Gao Guimin

Abstract excerpt

OBJECTIVE: For genome-wide association studies (GWAS) using case-control data with stratification, a commonly used association test is the generalized Armitage (GA) trend test implemented in the software EIGENSTRAT. The GA trend test uses principal component analysis to correct for population stratification. It usually assumes an additive disease model and can have high power when the underlying disease model is...

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Identifiers

PMID: 23571404
DOI: 10.1159/000350109
PMCID: PMC3786013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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