A robust method for testing association in genome-wide association studies.

Abstract excerpt

In genetic association studies, due to the varying underlying genetic models, no single statistical test can be the most powerful test under all situations. Current studies show that if the underlying genetic models are known, trend-based tests, which outperform the classical Pearson χ² test, can be constructed. However, when the underlying genetic models are unknown, the χ² test is usually more robust than...

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