TDP-43 Toxicity Proceeds via Calcium Dysregulation and Necrosis in Aging<i>Caenorhabditis elegans</i>Motor Neurons

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with either sporadic or genetic origins characterized by the progressive degeneration of motor neurons. At the cellular level, ALS neurons show protein misfolding and aggregation phenotypes. Transactive response DNA-binding protein 43 (TDP-43) has recently been shown to be associated with ALS, but the early pathophysiological deficits causing...

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