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Article

Distinct behavioral phenotypes in male mice lacking the thyroid hormone receptor α1 or β isoforms.

Hormones and behavior - 1 May 2013

Vasudevan Nandini, Morgan Maria, Pfaff Donald, Ogawa Sonoko

Abstract excerpt

Thyroid hormones influence both neuronal development and anxiety via the thyroid hormone receptors (TRs). The TRs are encoded by two different genes, TRα and TRβ. The loss of TRα1 is implicated in increased anxiety in males, possibly via a hippocampal increase in GABAergic activity. We compared both social behaviors and two underlying and related non-social behaviors, state anxiety and responses to acoustic and...

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Source

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Identifiers

PMID: 23567476
DOI: 10.1016/j.yhbeh.2013.03.015
PMCID: PMC3726275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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