Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.

Genes & development - 15 Sept 2005

Venero César, Guadaño-Ferraz Ana, Herrero Ana Isabel, Nordström Kristina, Manzano Jimena, de Escobar Gabriella Moreale, Bernal Juan, Vennström Björn

Abstract excerpt

The transcriptional properties of unliganded thyroid hormone receptors are thought to cause the misdevelopment during hypothyroidism of several functions essential for adult life. To specifically determine the role of unliganded thyroid hormone receptor alpha1 (TRalpha1) in neuronal tissues, we introduced a mutation into the mouse TRalpha1 gene that lowers affinity to thyroid hormone (TH) 10-fold. The resulting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gait Disorders, Neurologic
Share to Hypothyroidism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interneurons

Share to Memory Disorders

Share to Parvalbumins

Share to Radioimmunoassay

Share to Thyroid Hormone Receptors alpha

Share to Triiodothyronine

Source

Open in PubMed Open full text

Identifiers

PMID: 16131613
DOI: 10.1101/gad.346105
PMCID: PMC1221886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.PMID 16131613Read ↗

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.Semantic proximity Read ↗

Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal developmentSemantic proximity Read ↗

Severe psychomotor and metabolic damages caused by a mutant thyroid hormone receptor alpha 1 in mice: can patients with a similar mutation be found and treated?Semantic proximity Read ↗

Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform.Semantic proximity Read ↗

Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice.Semantic proximity Read ↗

A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.Semantic proximity Read ↗

Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice.Semantic proximity Read ↗

Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.Semantic proximity Read ↗

An unliganded thyroid hormone receptor causes severe neurological dysfunctionSemantic proximity Read ↗

A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice.Semantic proximity Read ↗

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo.Semantic proximity Read ↗

Distinct behavioral phenotypes in male mice lacking the thyroid hormone receptor α1 or β isoforms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.