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Article

TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2009

Sun Yuhua, Zupan Bojana, Raaka Bruce M, Toth Miklos, Gershengorn Marvin C

Abstract excerpt

Thyrotropin-releasing hormone (TRH) is a neuropeptide that initiates its effects in mice by interacting with two G-protein-coupled receptors, TRH receptor type 1 (TRH-R1) and TRH receptor type 2 (TRH-R2). Two previous reports described the effects of deleting TRH-R1 in mice. TRH-R1 knockout mice exhibit hypothyroidism, hyperglycemia, and increased depression and anxiety-like behavior. Here we report the...

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Source

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Identifiers

PMID: 19078951
DOI: 10.1038/npp.2008.217
PMCID: PMC2669701

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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