Mice with the testicular feminization mutation demonstrate a role for androgen receptors in the regulation of anxiety-related behaviors and the hypothalamic-pituitary-adrenal axis.

Abstract excerpt

Testosterone (T) appears to play a role in anxiety and sensorimotor gating in rodents, but whether T acts through the androgen receptor (AR) to influence these behaviors is less clear. We compared adult genetic male mice with the testicular feminization mutation (Tfm), which lack functional ARs, to wild type male littermates (wt males) on an assay of sensorimotor gating (prepulse inhibition of the acoustic...

Topics

• Adaptation, Ocular
• Adaptation, Psychological
• Androgen-Insensitivity Syndrome
• Animals
• Anxiety
• Behavior, Animal
• Exploratory Behavior
• Feminization
• Hypothalamo-Hypophyseal System
• Male