Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ.

doi:10.1210/endocr/bqae067

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Article

Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ.

Endocrinology - 1 Jul 2024

Hönes Georg Sebastian, Geist Daniela, Wenzek Christina, Pfluger Paul Thomas, Müller Timo Dirk, Aguilar-Pimentel Juan Antonio, Amarie Oana Veronica, Becker Lore, Dragano Natalia, Garrett Lillian, Hölter Sabine Maria, Rathkolb Birgit, Rozman Jan, Spielmann Nadine, Treise Irina, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valerie, Hrabe de Angelis Martin, Führer Dagmar, Moeller Lars Christian

Abstract excerpt

Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling). Whether noncanonical TR action contributes to the spectrum of TH effects is largely unknown. The aim of this study was to attribute physiological...

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PMID: 38889231
DOI: 10.1210/endocr/bqae067

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