Article
Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress.
Hormones and behavior - 1 Sept 2011
Zuloaga Damian G, Poort Jessica E, Jordan Cynthia L, Breedlove S Marc
Abstract excerpt
Testosterone influences the hypothalamic-pituitary-adrenal axis, anxiety-related behavior, and sensorimotor gating in rodents, but little is known about the role of the androgen receptor (AR) in mediating these influences. We compared levels of the stress hormone corticosterone at baseline and following exposure to a novel object in an open field in wild type (wt) male and female rats, and male rats with the...
Topics
- Androgen-Insensitivity Syndrome
- Animals
- Anxiety
- Behavior, Animal
- Corticosterone
- Female
- Hypothalamo-Hypophyseal System
- Male
- Mutation
- Pituitary-Adrenal System
- Rats
- Receptors, Androgen
- Reflex, Startle
- Stress, Psychological