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Article

Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2007

Zeng Hongkui, Schimpf Brian A, Rohde Alex D, Pavlova Maria N, Gragerov Alexander, Bergmann John E

Abstract excerpt

TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other antidepressive therapies. Two G protein-coupled receptors, TRH receptor 1 (TRH-R1) and TRH-R2, have been identified. Here we report the generation and phenotypic...

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Source

Identifiers

PMID: 17666589
DOI: 10.1210/me.2007-0048

Genes

TRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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