Evidence of clonal proliferation of hepatocytes after carbon-tetrachloride-induced hepatic injury in PGK-1 mosaic mice.

doi:10.1016/0378-4274(90)90168-l

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Article

Evidence of clonal proliferation of hepatocytes after carbon-tetrachloride-induced hepatic injury in PGK-1 mosaic mice.

Toxicology letters - 1 Jun 1990

Wada Y, Tsukada M, Kamiyama S, Koizumi A

Abstract excerpt

During aging processes, the liver is exposed continuously to both endogenous and exogenous chemicals which result in various degrees of hepatic damage. Hepatocytes maintain mitotic potential so that damaged cells are replaced by proliferation of selected clones of cells. Changes in the clonality...

Topics

Aging
Animals
Carbon Tetrachloride
Cell Division
Chemical and Drug Induced Liver Injury
Clone Cells
Female
Genetic Variation
Isoenzymes
Liver
Liver Diseases
Liver Regeneration
Mice
Mice, Inbred Strains
Phenotype
Phosphoglycerate Kinase

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