Article
Mutant frequency of lacI in transgenic mice following benzo[a]pyrene treatment and partial hepatectomy.
Mutation research - 9 Jun 1997
Shane B S, Lockhart A M, Winston G W, Tindall K R
Abstract excerpt
The Big Blue, transgenic mouse provides an in vivo mutation system that permits the study of pharmacodynamic parameters on mutant frequency (MF) following xenobiotic exposure. We have studied the effects of cellular proliferation on the frequency of mutations in the lacl transgene by evaluating t...
Topics
- Animals
- Bacterial Proteins
- Bacteriophage lambda
- Benzo(a)pyrene
- Blotting, Western
- Cell Division
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP1A2
- Enzyme Induction
- Escherichia coli
- Escherichia coli Proteins
- Hepatectomy
- Lac Repressors
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic